Christina Applegate, more stars open up about chronic illness, health issues

Jack Osbourne is opening up about his complicated relationship with multiple sclerosis, which he was diagnosed with in 2012.

Appearing on Christina Applegate and Jamie-Lynn Sigler's "MeSsy" podcast Nov. 3, the 40-year-old reality TV star admitted he sometimes feels "a bit like a fraud" when comparing his experience with others living with MS.

"I'll see people who were diagnosed a year ago, and they're in a much worse position," he said, explaining that his condition "hasn't stopped me and it hasn't really slowed me down."

Osbourne also acknowledged the emotional toll of the disease, including periods of depression.

"I have no control of how this thing is going to roll out in my body," he said, adding that he can control "how I'm choosing to treat it mentally to the best of my ability."

Judi Dench, 91, says her worsening eyesight has prevented her from acting.

The Oscar-winning actress, known for "Shakespeare in Love" and the James Bond franchise, was diagnosed with age-related macular degeneration in 2012.

"I can't be on stage. I can't do a play anymore. I can't do a film anymore. I can't read anymore," Dench told BBC Radio 4 in an Oct. 22, 2026 interview.

The condition affects central vision, making everyday activities difficult, according to Cleveland Clinic.

Dench previously revealed that she stopped driving and relies on friends to help her learn scripts, describing her growing dependence on others as "the most terrible shock to the system."

Oscar-winning actress Tatum O'Neal, 62, nearly died in May 2020 after overdosing on morphine, opiates and pain medication. The "Paper Moon" star suffered a stroke and spent six weeks in a coma.

"I almost died," O'Neal told People in 2023, revealing she had undergone extensive rehabilitation to regain her memory, speech and reading skills. She also opened up about her decades-long struggle with addiction.

"Every day, I am trying," she said of her sobriety journey.

In October 2026, O'Neal shared a rare Instagram selfie amid her continued recovery, smiling for the camera with a simple message: "Hope."

Milania Giudice, the 20-year-old daughter of "Real Housewives of New Jersey" star Teresa Giudice, opened up about her mental health struggles in an October 2026 social media video.

"I am bipolar. I struggle with depression, anxiety, PTSD and ADHD, and I am not ashamed of any of my mental health disorders because I'm currently in a treatment center," she said.

Giudice described the period as "the worst time of my life," following legal troubles and the death of a close friend. She said she hopes sharing her experiences will help others facing similar challenges.

"Hollywood Medium" star Tyler Henry has been open about the multiple surgical procedures he underwent to have cysts removed. After having surgery to remove a cyst growing in his brain in May 2025, the reality TV psychic required another procedure to address swelling as the cyst recurred.

Justin Timberlake shared in a July 2025 Instagram post that he has been diagnosed with Lyme disease, a bacterial illness usually contracted through tick bites.

"If you've experienced this disease or know someone who has — then you're aware: living with this can be relentlessly debilitating, both mentally and physically," he said. "When I first got the diagnosis I was shocked for sure. But, at least I could understand why I would be onstage and in a massive amount of nerve pain or, just feeling crazy fatigue or sickness."

Stray Cats frontman Brian Setzer shared in a Feb. 13, 2025, Instagram post that he had been diagnosed with an autoimmune disease that he vowed to "beat."

"Towards the end of the last Stray Cats tour I noticed that my hands were cramping up. I’ve since discovered that I have an autoimmune disease," he wrote alongside several photos of himself with his guitar. "I cannot play guitar. There is no pain, but it feels like I am wearing a pair of gloves when I try to play. I have seen some progress in that I can hold a pen and tie my shoes. I know this sounds ridiculous, but I was at a point where I couldn’t even do that."

In a March 2026 interview with Guitar Player Magazine, Setzer revealed that though his symptoms could return, he was ready to return to the stage after a year of treatment at Mayo Clinic.

"I was able to hold a guitar pick. That came first," he said. "It was, 'All right, I’m more than halfway there.' And then when I was able to fingerpick, when my fingers came back, then I had the whole package."

Katie Thurston, the Season 17 "Bachelorette" lead, revealed in a Feb. 15, 2025, Instagram post that she had been diagnosed with breast cancer.

"One thing I did early on was search other stories like mine. Other young women with breast cancer. Invasive ductal carcinoma. Mastectomy. Pregnancy after breast cancer. All of their stories helped," she wrote. "So I intend to be the same for others. This is day one of sharing and is going to be a long one. This first step of acceptance of my reality was the hardest. But I am ready to fight this."

Inaugural "Golden Bachelor" lead Gerry Turner revealed in December 2024 that he had been diagnosed with with Waldenström's macroglobulinemia, a bone marrow cancer.

"Unfortunately, there's no cure for it. So that weighs heavily in every decision I make," Turner told People of the disease. "It was like 10 tons of concrete were just dropped on me. And I was a bit in denial for a while, I didn't want to admit to it."

"Boy Meets World" star Danielle Fishel revealed in August 2024 that she had been diagnosed with breast cancer. In January 2025,she said she was officially done with radiation treatment and had moved on to taking a drug that prevents recurrence of the disease.

Actress Olivia Munn opened up in March 2024 that she had been diagnosed with breast cancer the prior year and had undergone a double mastectomy."I haven't felt like there was time to cry," she wrote in an Instagram post detailing her battle with the disease. "My focus narrowed and I tabled any emotions that I felt would interfere with my ability to stay clearheaded."

In 2025, Munn admitted that "I have years to go in my cancer treatment."

"The Office" star Jenna Fischer announced in October 2024 that she had undergone treatment for an "aggressive" form of breast cancer.

"October is breast cancer awareness month. I never thought I'd be making an announcement like this but here we are. Last December, I was diagnosed with Stage 1 Triple Positive Breast Cancer. After completing surgery, chemotherapy and radiation I am now cancer free," the actress wrote in an Instagram post at the time.

Musician Patti Scialfa, who is married to Bruce Springsteen, revealed in September 2024that she had been diagnosed with the rare blood cancer multiple myeloma.

"Every once in a while, I come to a show or two and I can sing a few songs onstage, and that’s been a treat." Scialfa, who is a member of Springsteen's E Street Band, said in the film "Road Diary.""That’s the new normal for me right now, and I'm OK with that," she added.

"Full House" star Dave Coulier revealed in November 2024that he had been diagnosed with stage 3 Non-Hodgkin lymphoma.

"I went from, I got a little bit of a head cold to I have cancer, and it was pretty overwhelming," the actor told People at the time. "This has been a really fast roller coaster ride of a journey."

Renowned singer Céline Dion revealed in December 2022 that she'd been diagnosed with a neurological disorder called stiff person syndrome. Dion's diagnosis forced the artist to cancel her entire 2023 tour.

"The spasms affect every aspect of my daily life, sometimes causing difficulties when I walk and not allowing me to use my vocal cords to sing the way I'm used to," Dion said in an emotional Instagram video. "I have to admit it's been a struggle. All I know is singing, it's what I've done all my life."

"Little House on the Prairie" star Melissa Gilbert shared in an August 2024 People interview that she has had been dealing with misophonia, a neurological disability, since she was a child. The disorder is characterized by feeling intense emotions toward repetitive sounds, such as chewing gum or tapping fingernails. The actress said the disorder caused issues on set.

"If any of the kids chewed gum or ate or tapped their fingernails on the table, I would want to run away so badly," Gilbert told the outlet. "I would turn beet red and my eyes would fill up with tears and I'd just sit there feeling absolutely miserable and horribly guilty for feeling so hateful towards all these people — people I loved."

The actress said menopause made her reactions worse. It wasn't until 2023 when she discovered there was treatment for the condition, and underwent 16 weeks of cognitive behavioral therapy. "I realized I could ride out these waves but that they're not going to go away," she said. "But now I have all these tools to enable me to be more comfortable and less triggered. It made me feel in control."

"Star Wars" actress Daisy Ridley shared in an interview with Women’s Health that she was diagnosed with the autoimmune disorder Graves' disease in September 2023.

Ridley, who plays Rey Skywalker, said her symptoms included a racing heart rate, weight loss, fatigue, hand tremors and irritability. Since being diagnosed, she has started daily medication and cut down gluten in her diet.

"I didn't realize how bad I felt before," Ridley told the magazine. "Then I looked back and thought, 'How did I do that?'" Ridley was previously diagnosed with endometriosis and polycystic ovary syndrome.

Singer Sara Evans shared on the "Sex, Lies, and Spray Tans" podcast that she had struggled with an eating disorder and body dysmorphia. The country star told host Cheryl Burke that being in the spotlight made her feel more self-conscious about her weight.

"My record label, every time I'd had a baby, they would be like, 'When's she gonna lose weight?'" she said. "So, things like that would get in my head."

She said social media comments also get to her, including once when someone once asked her, "What happened to your face?"

"I just wanted to respond like, 'How dare you?' I haven't done anything to my face. I've had Botox," she said. "You wanna know what happened to my face? I'm 52."

Mark Ruffalo revealed during a January 2024, episode of the "Smartless" podcast that he was diagnosed with a benign vestibular schwannoma when he was 33 years old.

The "Poor Things" actor said he had a dream about having a brain tumor that was "so intense" that he went to the doctor, who ordered him a CT scan. "You have a mass behind your left ear the size of a golf ball, and we don’t know what it is," he recalled being told. He had the mass removed but didn't tell his then-pregnant wife, Sunrise Coigney, until the night before he was due to undergo surgery.

The procedure left him with a "big" scar, and he was temporarily "totally paralyzed" on the left side of his face.

In early 2023, Jamie Foxx sparked concern when his daughter, Corinne, revealed the actor "experienced a medical complication."

Foxx explained in his 2024 Netflix special that he'd experienced "a bad headache" on April 11, 2023. Moments after he'd asked for an aspirin, he lost consciousness — and doesn't remember the ensuing 20 days. During this comatose period, Foxx was taken to a doctor, who administered a cortisone shot and sent him home. Then a follow-up appointment with a doctor revealed Foxx had experienced a stroke caused by a brain bleed. The exact cause of the stroke was not determined.

Foxx said he reemerged from his stroke-induced coma in May 2023. The "Blame It" rapper said he subsequently found himself in a wheelchair and was told he could no longer walk. He worked to regain his mobility and made his first major public appearance in December.

"I lost everything, but the only thing I could hold onto was my sense of humor," Foxx said. "I couldn't necessarily walk that good, I couldn't talk that good, but I didn't let go of my funny."

Chappell Roan sparked concern in April 2023 after being hospitalized for a mysterious illness.

The comedian later revealed in a Netflix special that he had suffered a stroke caused by a brain bleed. The exact cause of the stroke was not determined.

Model and socialite Lori Harvey revealed she has been battling polycystic ovary syndrome (PCOS) and endometriosis — diseases originating in the reproductive system that don't have known causes — for years. In a September 2025 episode of the "She MD Podcast," the entrepreneur said gynecologists dismissed her symptoms for years before she received a proper diagnosis.

"The Real Housewives of Beverly Hills" alumna Teddi Mellencamp revealed in 2022 that she had been diagnosed with stage 4 melanoma and by 2025, the cancer had metastasized to her lungs and brain.

In October 2025, Mellencamp said there was "no detectable cancer" in her body, but she'd remain "on immunotherapy for another year" and is "not considered in remission or anything like that."

Grammy-winning rapper Macklemore (born Ben Haggerty) has been candid about his struggles with addiction. The rapper is also a vocal advocate for destigmatizing the issue.

"I am a recovering addict, [an] alcoholic and have been for the last 14 years," the "Thrift Shop" singer said during a 2023 "Tonight Show" appearance. Macklemore has touted inpatient treatment and 12-step meetings as key to his recovery.

In a January 2022 essay for Today.com, Macklemore elaborated on the relapses he has experienced. "Relapsing is always hard. It’s traumatic for myself and for my family. I’ve had three relapses in the last six years. The amount of pain and damage that I can do very quickly in losing the trust of others happens instantaneously," he wrote.

"I know that addiction is a treatable disease, but I’m never going to be cured, and I’m completely fine with that."

In his memoir "If You Would Have Told Me," John Stamos got candid about his battle with alcoholism, which surfaced during a 2002 Broadway run as Emcee in "Cabaret." What began as “liquid courage” to get through the show became a ritual of "drinking a bottle of wine every performance."

The actor’s addiction came to a head in 2015 when he was charged with a misdemeanor DUI after driving intoxicated through the streets of Beverly Hills, California. Following the incident, Stamos began his sobriety journey with an Alcoholics Anonymous treatment program in Utah. He says getting sober has played "a big part [in] my fairytale ending."

"Addiction runs rampant these days, and I just wanted to show people that if I could get through it, then anyone can," Stamos told USA TODAY. "And without it, if I didn’t sober up, I would not have a family. I would not have a son. I would not have a wife. I don’t even know if I’d be alive."

During an appearance on the "Call Her Daddy" podcast in November 2023 actress Lucy Hale detailed her struggle with alcohol and an eating disorder, which she said were exacerbated at the height of her fame on "Pretty Little Liars."

The "PLL" alum said her drinking became a regular activity after turning 18, but she "didn't realize I had a problem until my early 20s." Hale revealed she secretly went to rehab when she was 23 while filming the show. The "Truth or Dare" star eventually got sober in 2021, which she credits in part to getting COVID-19, because it forced her to stay home and receive medical treatment.

Model and actor Cara Delevingne candidly discussed her sobriety journey in an interview with Vogue in April 2023.

She recalled the experience of seeing paparazzi photos of herself looking haggard shortly after her 30th birthday as a wake-up call. She took the photos as a sign to step back from alcohol and other substances that she had been using to avoid personal struggles. Later in 2022, the "Only Murders in the Building" actress checked herself into rehab.

In 2018, Neil Diamond revealed he'd been diagnosed with Parkinson's disease.

"I was in denial for the first year or two," Diamond said in a candid interview with "CBS Sunday Morning" in April 2023.

"I don't like it. But this is me; this is what I have to accept. And I'm willing to do it," he said. "This is the hand that God's given me, and I have to make the best of it, and so I am."

John Mulaney has been open over the years about his battle with addiction. In his 2023 Netflix standup special, "Baby J," Mulaney shared that in January 2020 he was "very addicted to cocaine" and detailed the elaborate ways he'd bypass his own security to obtain drugs. He joked about having a "star-studded intervention" in 2020 and using cocaine multiple times on the way to rehab.

"It’s weird to be a recovering drug addict," he said. "It was weird to be a drug addict, but at least I was on drugs. It's strange sometimes. Like, I’m doing great, but when I’m alone, I'm with the person that tried to kill me."

"Jurassic Park" star Sam Neill revealed in his 2023 memoir "Did I Ever Tell You This?" that he had been diagnosed with Stage 3 angioimmunoblastic T-cell lymphoma.

Every two weeks, Neill said, he was getting infusions of a drug that his tumor had been responding to well. He said he planned to keep doing this indefinitely, until the treatment inevitably stopped working, he shared in a 30-minute documentary released in October 2023 by Australian Broadcasting Corporation.

It's like "going 10 rounds with a boxer, but it's keeping me alive, and being alive is infinitely preferable to the alternative," Neill said.

Actor Edward James Olmos spoke publicly for the first time in May 2023 about his throat cancer diagnosis in an episode of "Mando & Friends" podcast.

"December 20 was my last radiation. This week before, I'd finished my chemo and [for] months and months I was on radiation and chemo as it attacked my throat," he said. "I still have right here [on my throat] a bump where my lymph nodes, they burned them out because they shot this area with radiation."

Despite the diagnosis and the strain it took on his body, Olmos said he feels "in good condition. … It was an experience that changed me, the understanding of how wonderful this life is. I've been through some experiences that have gotten me close to death, but that was close."

Disney Channel star Ashley Tisdale has been open about her struggle with alopecia, the medical term for hair loss. In a video posted in January 2023 on Instagram, Tisdale shared that she first experienced it in her 20s at the front of her hairline and again after dealing with moving, a home renovation and a TV project.

"Nothing major – just a small section behind my ear – but still, it was happening, and not for the first time. A few years ago, the same thing happened when I was overly stressed, so I knew exactly what I was experiencing: alopecia," she wrote.

Although the actress said she was initially "embarrassed" to talk about it, she's found strength in others who have. Tisdale said her alopecia is largely stress-related and found prioritizing self-care, an autoimmune paleo diet and platelet-rich plasma treatment when she is experiencing hair loss are some treatments that have helped.

Nick Cannon revealed in 2012 that he had been diagnosed with lupus. In January 2022, the TV personality looked back at his health journey 10 years after his diagnosis.

"Just a few days ago I was with my family in the snow, playing, having a good time," he said in a video testimony. "All of a sudden I started swelling up, had shortness of breath, excruciating pain in my right side."

In December 2022, the comedian and actor posted a photo from a hospital bed on Instagram saying he'd come down with pneumonia a day after hosting "Wild N' Out Live" at Madison Square Garden. "So I guess I’m not Superman ... I promised myself I would never be back at this place again. ... But this is a great lesson to take care of YOU or YOU won’t be able to take care of everyone else," he wrote with the hashtag #LupusWarrior. 

Country singer Devin Dawson opened up on Instagram in November 2022 about his dysphonia diagnosis, which he says has "severely affected my talking voice and my singing voice in the lower ranges." The "All on Me" singer said he'd been struggling with the condition for almost 10 months. 

"One of the hardest parts of this has been just getting everyone up to speed individually and having to almost relive how much it sucks not to be able to talk or sing the way I want to," Dawson wrote on Instagram. "Nobody wants me to make another record more than I do. I promise you that. And I will." 

Johns Hopkins Medicinedescribes muscle tension dysphonia as " a change in the sound or feel of your voice due to excessive muscle tension in and around the voice box." 

CNN anchor Kasie Hunt has been open about having a brain tumor removed. In a thread posted to X in October 2022, Hunt shared that she was "completely healthy and can physically live my life as though it never happened."

But Hunt said she "learned so much" from the experience, including the importance of personal health and relationships. "Most people aren’t forced to grapple with the real possibility they’ll be gone when they are still otherwise young and healthy," she wrote.

Katie Couric revealed in aSeptember 2022 essay on her website that she was diagnosed with breast cancer after a mammogram detected abnormal results.

Couric appeared on "Today" with her former co-anchors Hoda Kotb and Savannah Guthrie soon after and revealed she "finished radiation last week."

"['m] just so grateful that they caught it early enough so it could be treated," she said. Couric has been an advocate for regular health screenings since her first husband Jay Monahan died from colon cancer in 1998.

"West Side Story" star Rachel Zegler took to social media in September 2022 to share her experience with a breast cancer scare when she was 19. 

"Two years ago I found a lump in my breast and went through what was undoubtedly the scariest week of my life," she wrote on her Instagram stories, per E! News. "No OB/GYN was taking new patients due to the backlog of the pandemic, but I was fortunate to have the care of my pediatrician who prescribed me an ultrasound, which led to an outpatient biopsy procedure."

"Thankfully it was benign, and now the scar serves as a reminder to check my breasts regularly for any irregular growth – the fibroadenoma in my left breast is a common occurrence but nevertheless extremely scary to find," she said. "Early detection saves lives!!!!" 

Actress and singer Maureen McGovern revealed on her website in August 2022 that she was "diagnosed with posterior cortical atrophy with symptoms of Alzheimer’s and/or dementia."

"I struggled with the inevitable shock with fear and frankly hopelessness," she wrote. "But slowly I realized that my inner life has not changed. My passion for music, for singing, remains profoundly robust."

Posterior cortical atrophy "refers to gradual and progressive degeneration of the outer layer of the brain, in the part of the brain located in the back of the head," according to the Alzheimer's Association.

In her 2022 Netflix documentary "Shania Twain: Not Just a Girl," the country music icon opened up about the physical toll Lyme disease took on her singing voice. Twain said she contracted the disease toward the end of her Up! Tour (which ran from 2003 to 2004) after a tick bit her while she was riding a horse.

"My symptoms were quite scary because before I was diagnosed, I was onstage very dizzy. I was losing my balance. I was afraid I was going to fall off the stage," Twain revealed. "I was having these very, very, very millisecond blackouts, but regularly, every minute or every 30 seconds."

Despite releasing the No. 1 album "Now" in 2017, the Grammy-winning singer said her "voice was never the same again." She continued, "I thought I'd lost my voice forever."

"Game of Thrones" actress Emilia Clarke revealed in March 2019 that she'd suffered two life-threatening brain aneurysms during her time on the HBO drama. 

Clarke opened up more about the health ordeal in an interview with BBC's "Sunday Morning" in July 2022. "The amount of my brain that is no longer usable – it's remarkable that I am able to speak, sometimes articulately, and live my life completely normally with absolutely no repercussions," she said. "I am in the really, really, really small minority of people that can survive that."

Emily Blunt hosted the American Institute for Stuttering's Freeing Voices, Changing Lives gala in July 2022, and discussed how acting helped with her stutter.

Blunt began to notice her stutter around age 6 or 7, she told People magazine. "It's biological and it's often hereditary and it's not your fault. And I think it's very often a disability that people bully and make fun of," she said.

"General Hospital" actor Cameron Mathison told People magazine in June 2022 that he had undergone surgery to treat kidney cancer in 2019. 

"I work with a health coach now – I thought I knew a lot about what I was doing in the right and the wrong ways or whatever, but in the last year, I'd say, maybe 14 months, I've learned more about my own specific health challenges and growth than I have probably in decades before that," Mathison told the outlet.

Justin Bieber, who's been open in the past about his Lyme disease diagnosis and contracting "a serious case of chronic mono," revealed in a June 2022 Instagram post that he has Ramsay Hunt syndrome, a neurological disorder characterized by facial nerve paralysis.

"As you can see, this eye is not blinking," Bieber said in the video, referencing the left side of his face. "I can't smile on that side of my face. This nostril will not move. So there's full paralysis on this side of my face."

"I'm doing all these facial exercises to get my face back to normal, and it will go back to normal," he continued. "It's just time, and we don't know how much time it's gonna be, but it's gonna be OK. And I have hope, and I trust God, and I trust that... it's all for a reason."

NSYNC singer Lance Bass revealed to People in a May 2022interview that he was diagnosed with psoriatic arthritis. Bass told the outlet that he had been diagnosed five years prior after experiencing debilitating symptoms for some time. 

"I had symptoms before, but I kind of just dealt with it, not knowing exactly what it was. I was a dancer my whole life, so I just kind of figured it was because of dancing," he said.

"It definitely started in my shoulders and then in my knees," he said. "And again, to me, that was just such a sign of dancer pain, so I just thought it was completely normal, totally ignoring the signs."

In May 2022, Halsey opened up to fans on social media about receiving a slew of new health diagnoses after spending time in the hospital. "My health has changed a lot since I got pregnant and gave birth," the singer said in a series of Instagram stories.

"I started getting really, really, really sick. I've been kind of sick most of my adult life, but it started getting really bad [after giving birth]," Halsey said, noting they are "allergic to literally everything" and were hospitalized for anaphylaxis.

The singer then said they were was diagnosed with Ehlers-Danlos syndrome, Sjogren's syndrome, mast cell activation syndrome and postural orthostatic tachycardia syndrome (POTS). 

Hailey Bieber opened up about the "scariest moment of my life" in April 2022. In a YouTube video titled "telling my story," the model talked about a recent health scare, revealing she had a follow-up procedure after her March "mini-stroke" to close a hole in her heart. Bieber began the video by saying the day had a typical start, with her and Justin Bieber sitting for breakfast together.

"We were in the middle of talking, and all of a sudden I felt this really weird sensation that traveled down my arm from my shoulder all the way down to my finger tips," she said. When Justin asked if she was OK, Bieber said she "couldn't speak" and that "the right side of my face started drooping. I couldn't get a sentence out." She added: "Immediately, I thought I was having a stroke, like a full-blown stroke."

Karen Duffy, former MTV VJ and model, opened up about her life with chronic pain in her new book "Wise Up: Irreverent Enlightenment from a Mother Who's Been Through It.'" Released April 12, 2022, it is written in the form of letters to her teenage son, Jack. Duffy has endured a long battle with sarcoidosis, a disease characterized by the growth of tiny collections of inflammatory cells in any part of your body. But she has found meaning in her health journey.

"I always try to think, 'What is the upside to having your life turned upside down?' Maybe it's to appreciate every moment — and have a sense of deeper compassion for people living with chronic pain," she told People in April 2022. "My body may be breaking down, but my spirit is ginning up. I wanted to express gratitude for my life."

Brian Austin Green revealed to social media followers in April 2022 that he had been "pretty bedridden" while dealing with ulcerative colitis for six weeks.

Ulcerative colitis is an "inflammatory bowel disease that causes inflammation and ulcers (sores) in your digestive tract," according to the Mayo Clinic. 

Green expressed gratitude to Sharna Burgess, his girlfriend at the time, for taking care of him and his children while he was recovering. "I'm back now. I'm feeling good. Thank goodness," he said in an Instagram video. "It was a terrible experience. I'm glad it's over."

Selma Blair revealed in 2018 that she had been diagnosed with multiple sclerosis and has continued keeping social media followers in the loop with candid posts about her highs and lows with the disease.

The chronic autoimmune disease has caused caused the actress to experience symptoms that make her "hurt all the time." However, in April 2025, the "Cruel Intentions" star shared a positive update, revealing she'd been "feeling great" for a year. "I spent so much of my life so tired from being unwell that I think I just was trying to get through the day," she said. "And now it's like, wait, I realize I don't know what my goals are."

Stanley Tucci first revealed in September 2021 that he was diagnosed with cancer at the base of his tongue in 2017. Since then, he's opened up more about his battle, telling People magazine in March 2022 that he is "incredibly lucky" to be alive.

"They couldn't do surgery because the tumor was so big. It's a miracle that it didn't metastasize. It had been in me so long," the "Devil Wears Prada" star said, noting that he struggled with taste and smell for years. He credited his wife Felicity's "undying attention" for helping him through it, and he is now cancer free and enjoying foods again.

In a video posted to Instagram on Dec. 28, 2021, actor and singer Jada Pinkett Smith opened up to fans about her ongoing struggle with alopecia, the autoimmune disease that often causes hair to fall off the scalp in "small, round patches," according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. 

"Now at this point, I can only laugh," Smith said in the video, in reference to a new bald line spot. "It just showed up like that, and this is going to be a little bit more difficult for me to hide, so I thought I'd just share it so y'all are not asking any questions."

While discussing COVID-19 vaccine mandates and Colin Powell on his talk show "Inside Politics," CNN anchor John King shared on Oct. 19, 2021, that he has multiple sclerosis, a disease of the central nervous system. "I am grateful my employer says all of these amazing people who work on the floor — who came in here in the last 18 months when we are doing this — are vaccinated now that we have vaccines," King said.

Rachel Maddow revealed on her primetime show in October 2021 that she was diagnosed with skin cancer and underwent surgery to remove the malignant cells. "I want to use this moment to tell you something, which is: You should get checked," the political commentator said. She added that her surgery was successful.

During a September 2021 appearance on "Rachael Ray," "Good Morning America" anchor Robin Roberts spoke about her previous myelodysplastic syndrome diagnosis and how she needed a bone marrow transplant surgery to survive. "My doctor told me I had a year or two to live if I didn't have a successful transplant," she recalled.

It was Roberts' sister, Sally-Ann, who eventually became her donor. "My other siblings were not a match... It came down to my sister Sally-Ann," she said. "My sister said, 'Not only is this something I want to do, I feel I was born to be [your donor].'"

Sofía Vergara opened up about being diagnosed with thyroid cancer two decades prior during the Stand Up To Cancer 2021 telecast.

"At 28 years old, during a routine doctor's visit, my doctor felt a lump in my neck. They did a lot of tests and finally told me I had thyroid cancer," the "Modern Family" star said. "I tried not to panic and I decided to get educated… I also learned that in times of crisis, we're better together."

Yvette Nicole Brown says she developed "full-blown diabetes" while filming "Community," in which she portrayed Shirley Bennett, after "excessively eating sugar" on set. On Dr. Priyanka Wali and Sean Hayes' "Hypochondriactor" podcast, she said, "I got diabetes, or gave myself diabetes, by eating a lot of donuts on the set of 'Community.'"

She continued: "I spent a lot of time at the craft services table, and I watched myself get bigger and bigger. And if you watch the show, you can see me get bigger and bigger. And I got a pre-diabetes diagnosis maybe in Season 1, and then by Season 3 it was full-blown diabetes."

Since her Type 2 diabetes diagnosis, Brown said she's cut down her sugar intake but hasn't cut it out completely: "I believe everything [should be taken] in moderation."

Jessie J opened up on Instagram about how acid reflux has affected her ability to sing. The "Bang Bang" singer was diagnosed with Meniere's disease in 2020 after being hospitalized for having problems with her hearing and balance.

"I woke up and felt like I was completely deaf in my right ear, couldn’t walk in a straight line," Jessie J said on Instagram Live.

The singer gave her followers an update on her health in June 2021, saying that the steroids she took for her ear problems caused her to have major acid reflux and nodules on her vocal chords. 

"Every doctor has told me if I sing ... the nodules will just come right back," she wrote on June 18 on her Instagram story.

According to Mayo Clinic, Meniere's disease is a "disorder of the inner ear that can lead to dizzy spells (vertigo) and hearing loss." It's a chronic condition that can be relieved with various treatments and medications.

Mayim Bialik revealed on her podcast "Mayim Bialik’s Breakdown" in March 2021 that she'd been in recovery for anorexia.

"This is the first time I've ever talked about it, because people are like, 'Well, why are you so overweight?' Well, because I'm a compulsive overeater in addition to being an anorexic and restrictor," Bialik said while speaking with author Glennon Doyle.

In a post to Instagram on Dec. 1, 2020, Keke Palmer opened up about her struggle with adult acne. "Polycystic ovarian syndrome has been attacking me from the inside out my entire life and I had no idea," she revealed in the post, where she put her bare skin on display. She also explained all the ways she tried to manage her acne.

"The least harmful thing PCOS can bring is acne. To all the people struggling with this please know you’re not alone and that you are still so ... fine!" she added.

On the Nov. 6, 2020, episode of the "Today" show, longtime weatherman and co-host Al Roker announced he had been diagnosed with prostate cancer and would be undergoing surgery.

Roker was also hospitalized in November 2022 for blood clots in his leg that traveled to his lungs and had to step away from the cameras again the following month to treat two bleeding ulcers: "I went in for one operation, I got four free," he joked when he returned to the "Today" show in January 2023 after two months away.

He later revealed on a podcast that he'd "almost died" from his medical issues, but his family shielded him from knowing the extent of the complications he'd experienced.

In October 2020, Arnold Schwarzenegger revealed that he recently had a "new aortic valve" implanted in his heart.

"Thanks to the team at the Cleveland Clinic," Schwarzenegger captioned several photos, including one of him flashing a thumbs up in his hospital bed. "I feel fantastic and have already been walking the streets of Cleveland enjoying your amazing statues. Thank you to every doc and nurse on my team!"

Schwarzenegger was born with a congenital heart defect. He previously had heart surgery in 2018 and 1997.

In October 2020, Jeff Bridges revealed on social media that he'd been diagnosed with lymphoma, a cancer of the lymphatic system. 

"As the Dude would say.. New [expletive] has come to light," Bridges wrote on Twitter, referencing his 1998 cult classic "The Big Lebowski." "Although it is a serious disease, I feel fortunate that I have a great team of doctors and the prognosis is good."

In January 2021, Bridges updated fans, saying his tumor "drastically shrunk." Months later, in September, the actor said his cancer was in remission. 

In 2020, Tamar Braxton opened up about her ongoing battle with mental health nearly two weeks after her hospitalization following a suicide attempt. "Mental illness is real," she wrote in a lengthy message on Instagram. "We have to normalize acknowledging it and stop associating it with shame and humiliation. The pain that I have experienced over the past 11 years has slowly ate away at my spirit and my mental."

She continued: "I will do everything in my power to aid those who [struggle] from mental illness... It was only God’s grace and his mercy on my attempt to end my pain and my life that I am here to utilize my voice. "

If you or someone you know may be struggling with suicidal thoughts, you can call 988 any time day or night, or chat online. Crisis Text Line also provides free, 24/7, confidential support via text message to people in crisis when they dial 741741.

"Beverly Hills, 90210" alum Shannen Doherty revealed on "Good Morning America" in February 2020 that she had been privately living with cancer. Her attorney confirmed to USA TODAY at the time that her breast cancer, which she was first diagnosed with in March 2015, had metastasized and she suffered from a chronic respiratory illness.

She shared updates on the progression of the disease over the years, revealing in June 2023 that a CT scan months prior showed the cancer had spread to her brain. She died July 14, 2024.

In an interview with Vogue in January 2020, Katy Perry spoke out about battling depression, saying between 2017 and 2018 she was depressed in a way she'd never experienced.

"I became depressed, and I did not want to get out of bed. In the past, I had been able to overcome it, but this time something happened that made me fall down too many flights of stairs," she said. "I had to really go on a mental health journey."

Perry said she wrote her album, "Smile," while she was "coming through one of the darkest periods of my life. ...This whole album is my journey towards the light — with stories of resilience, hope and love."

Kelly Clarkson opened up about her own battle with depression during a conversation with Demi Lovato on "The Kelly Clarkson Show" in June 2020.

"I love how open you are about mental health, because I have similar issues," Clarkson said in a clip. "I've suffered from depression."

Paris Jackson opened up about her struggles with self-harm and body image issues in a July 2020 episode of the Facebook Watch series "Unfiltered: Paris Jackson and Gabriel Glenn." 

Jackson said she "fell into self-harm" when she gained weight following her father's death in 2009. "It was also a distraction from emotional pain and transferring it to physical pain. And a need for control," she said, adding that her depression "comes in waves."

"Real Housewives of New York" star Ramona Singer revealed in March 2020 that she was diagnosed with Lyme disease. "We caught it early, and I’m very lucky and very blessed,” she told E! News.

"Sopranos" star Jamie-Lynn Sigler first opened up about her MS diagnosis in 2016 after battling the disease privately for 15 years.

In a 2020 interview with People, Sigler shared that although she has her bad days and sometimes wished she didn't have MS, she knew she wouldn't be who she is without it.

"I am dealing with it the best I can. I'm still independent. I just went on a trip alone to Punta Cana with my son," she said. "I'm still able to work, and I have the energy to do all these things. ... Soes it slow me down physically in certain ways? Sure, but I've figured out in the 18 years of living with it how best to function, and I don't feel like I'm missing out on anything in life."

Actress Taraji P. Henson opened up about seeing a therapist to help her cope with depression and anxiety. "There are some times where I feel absolutely helpless. That's human. Everybody feels like that,” she told Self magazine in December 2019. "That means talking to my therapist when I feel this way, doing things to get me out of the muck."

In 2018, Henson launched her nonprofit, the Boris Lawrence Henson Foundation (named after her father, who also struggled with mental health issues), to combat the stigma around mental health in the African American community.

After she was photographed using a cane, Lena Dunham revealed in November 2019 that she has Ehlers-Danlos syndrome. 

"The truth is just: This is what life is like when I’m struggling most with chronic illness. An Ehler-Danlos syndrome flare means that I need support from more than just my friends... so thank you, sweet cane!" she wrote on Instagram.

Dunham also underwent a total hysterectomy, which removes a woman's cervix and uterus, in November 2017 to relieve severe pain caused by her endometriosis, a disorder where tissue that normally lines the uterus grows in other areas of the body. She had more than a dozen surgeries related to the disorder.

Jamie Lee Curtis has been open about her sobriety. "As soon as I got sober, which is 20 years coming up in February, everything changed," she told USA TODAY in October 2018. "Because it was a big, big acknowledgment that I could not do all of the things I was trying to do."

Jonathan Van Ness, the grooming expert on Netflix's "Queer Eye," revealed in September 2019 that they are HIV-positive.

"At the beginning [of 'Queer Eye'] I was really kind of nervous to talk about my HIV status and not sure if I wanted to and how I wanted to," Van Ness told USA TODAY. "And as I’ve continued to experience the world as I always have, it just became more clear to me that I wanted to be totally open with my story and be able to talk about it, especially in the face of [the Trump] administration."

Sarah Hyland has been vocal about living with kidney dysplasia, a condition that arises after abnormal kidney growth in the womb. She's had two kidney transplants and wants fans to know that having health issues is "not shameful."

She said in a 2018 interview with Self: "For anybody that wants to reach out to somebody but doesn't really know how because they're too proud or they think that they'll be looked upon as weak, it's not a shameful thing to say. It's not a shameful thing to share." She has also been diagnosed with endometriosis.

In Jane Fonda's words, she's had "a lot of cancer." But the actress, now in her 80s, continues to work after sharing multiple stories of tumor removals. 

Normally a pretty private person, Julia Louis-Dreyfus went public with her breast cancer battle in 2017 in part because "Veep" production was about to start, but also because she saw it as an opportunity to influence lawmakers to fight for universal health care.

"My hand was kind of forced by virtue of the fact that we were about to start production, and I had 150 or 200 people waiting to get going on this show. So I thought, 'OK, let's make a virtue, if you can, of such a horrible moment,'" she told USA TODAY in 2019. Louis-Dreyfus announced in October 2018 that she was cancer-free.

Nick Jonas announced to fans during his early Jonas Brothers days that he has Type 1 diabetes. In 2018, he shared on Instagram that he prioritizes "physical health, working out and eating healthy and keeping my blood sugar in check," and reminded fans not to "let anything hold you back from living your best life."

"Jane the Virgin" star Gina Rodriguez has dealt with thyroid issues since she was 19 and was diagnosed at 26 with Hashimoto’s autoimmune disease, which can cause fatigue, memory loss, joint pain and weight gain. And the actress has been vocal about the ways she initially felt defeated by the disease, before deciding to tackle it head-on.

Her Hashimoto's diagnosis felt like "the curse of a lifetime," she told Self magazine in 2018. But she figured out a diet and fitness regiment that helped her reclaim her body. When she avoids foods she's identified as problematic for her system, "so many of my ailments are gone," she said.

"It feels like freedom. This is new. I'm 33. It's taken me a while."

Gabrielle Union has adenomyosis, where endometrial tissue that typically lines the uterus grows into the outer muscular walls of the organ. The actress revealed to Essence in 2018 that the condition meant it took a while for her and husband Dwyane Wade to conceive.

"Towards the end of my fertility journey I finally got some answers, because everyone said 'You’re a career woman' you’ve prioritized your career. You waited too long and now you’re just too old to have a kid – and that’s on you for wanting a career," she said. "The reality is I actually have adenomyosis."

Michael J. Fox has publicly battled Parkinson's disease for more than three decades. In 2018, he opened up about undergoing a spinal surgery and enduring difficult physical therapy sessions afterward. 

Over the years, Fox has sustained multiple broken bones, including both arms, his shoulder, his orbital bone and cheek and his hand, which resulted in a serious infection. Fox combats his symptoms, such as paralysis of his facial muscles, through medication and trains to preserve his ambulatory skills.

In 2025, President Joe Biden awarded him the Presidential Medal of Freedom as he "warms hearts and captivates audiences as a fearless advocate for those with Parkinson's disease."

Selena Gomez has publicly discussed her experiences with lupus and bipolar disorder diagnoses, including in her Apple TV+ documentary, "Selena Gomez: My Mind & Me."

In 2017, Gomez revealed she'd undergone a transplant to receive a kidney donated by her friend, Francia Raísa. In an interview with "Today" later that year, she described the procedure as a "life-or-death" move.

She said she underwent the transplant as part of her fight against lupus, an autoimmune disease that often attacks the kidneys. The singer also underwent chemo as part of her treatment.

Fellow Disney Channel star Demi Lovato has publicly struggled with addiction and an eating disorder. In a 2017 documentary, Lovato revealed they still hadn't "conquered" the eating disorder and faced a relapse after splitting with their boyfriend of six years, Wilmer Valderrama. "Food is still the biggest challenge in my life," they revealed in the documentary.

Lovato said in a July 2023 interview that they are sober and in "a more positive mind space" nearly five years after an overdose left them with vision and hearing impairments.

"That overdose caused ... a disability. I have vision impairment and hearing impairment to this day," they said on "Andy Cohen Live." "It's a daily constant reminder. You know, anytime I look at something, like, I have blind spots in my vision when I look at your face. And so it's a constant reminder to stay on the right path because I never want that to happen again."

Lovato previously revealed in their 2021 docuseries "Demi Lovato: Dancing With the Devil" that they experienced several strokes, a heart attack, pneumonia and multiple organ failure as a result of their near-fatal overdose in July 2018. This left them "legally blind when I woke up," but they regained some eyesight after.