NFL Week 5 picks straight up and against spread: Do Chiefs continue surge against Jags?
Nate Davis- The Vikings and new-look Browns kick off Sunday in London.
- "Sunday Night Football" features an AFC East clash between the Bills and Patriots.
- Week 5 ends Monday with surging Chiefs trying to ruin the Jags' return to the prime-time stage.
The 2025 NFL season has somehow already reached October. That means loads of international games, the onset of bye weeks and even quarterback switches.
Week 5 will usher in byes for some of the league's most prominent players and teams, the Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers all taking their break. The schedule will kick off for the second straight Thursday night with a battle of NFC West rivals, the Los Angeles Rams hosting the battered San Francisco 49ers.
Sunday morning brings the season's first game of the year in London, where the Minnesota Vikings will encounter the Cleveland Browns and their new QB1, Dillon Gabriel. The rest of the day isn't exactly packed with marquee matchups, though Broncos-Eagles, Buccaneers-Seahawks and Commanders-Chargers all have high-end potential. The Buffalo Bills host the New England Patriots on Sunday night.
Week 5 wraps Monday evening when the Jacksonville Jaguars, hosting their first Monday night game in two years, face the surging Kansas City Chiefs in what the Jags hope is rookie WR/CB Travis Hunter's NFL coming-out party.
Who wins? Who doesn't? Our panel of USA TODAY Sports NFL experts weighs in.
NFL Week 5 picks, predictions and odds
- San Francisco 49ers at Los Angeles Rams
- Minnesota Vikings at Cleveland Browns
- Miami Dolphins at Carolina Panthers
- Las Vegas Raiders at Indianapolis Colts
- New York Giants at New Orleans Saints
- Houston Texans at Baltimore Ravens
- Denver Broncos at Philadelphia Eagles
- Dallas Cowboys at New York Jets
- Tennessee Titans at Arizona Cardinals
- Tampa Bay Buccaneers at Seattle Seahawks
- Detroit Lions at Cincinnati Bengals
- Washington Commanders at Los Angeles Chargers
- New England Patriots at Buffalo Bills
- Kansas City Chiefs at Jacksonville Jaguars
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