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NFL

Giants at Patriots: Predictions, picks, odds for Monday Night Football Week 13

Nov. 26, 2025, 4:06 a.m. ET

The New York Giants (2-10) visit the New England Patriots (10-2) at Gillette Stadium in Foxborough for a Week 13 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff on Monday, December 1, including live updated odds and injury report news.

NameWeek 122025 Season
Jon Hoefling5-8-189-85-4
Blake Schuster4-9-187-74-4
Tyler Dragon6-7-188-86-4
Chris Bumbaca5-8-183-91-4
Lorenzo Reyes5-8-182-92-4
Jordan Mendoza4-9-168-77-3
Richard MorinN/A25-12-1

Patriots vs. Giants live odds, moneyline, over/under

Opening Lines

  • Spread: Patriots (-3)
  • Moneyline: Patriots (-170), Giants (+140)
  • Over/Under: 42.5

Get the edge with our exclusive NFL betting picks

Patriots vs. Giants picks against the spread

Tyler Dragon: New England Patriots (-7.5)

The Patriots are the lone 10-win football team entering Week 13. This is a primetime spot for New England to make a statement.

Jon Hoefling: New York Giants (+7.5)

The Patriots have been slipping a bit of late. And while I dont expect the Giants to win, Big Blues defensive line could give the Pats some fits.

Blake Schuster: New England Patriots (-7.5)

While Jameis Winston does his best Eli Manning impression, I'm sticking with a New England team that continues to impress on both sides of the ball.

Jordan Mendoza: New England Patriots (-7.5)

Jameis Winston has made the Giants fun to watch, but going on the road in New England? That's too much to ask for against the NFL's hottest team.

Lorenzo Reyes: New England Patriots (-7.5)

The Giants are unpredictable, and the Patriots failed to cover what was a substantial spread. I think New England course corrects, though it really has benefitted from an incredibly easy schedule.

Richard Morin: New York Giants (+7.5)

The Patriots burned backers in Week 12. The Giants, somewhat surprisingly, are showing a lot of competitiveness despite an injury-ravaged roster.

Patriots vs. Giants updated injury report

NFL Week 13 picks, predictions, odds

Super Bowl 60 updated odds

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Information in this article was imported automatically into a template written and reviewed by a USA TODAY Sports editor. You can send feedback using this form.

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