NFL Week 1 betting odds, spreads for every game after schedule release

The 2026 NFL schedule has been released, and football fans now know who all of their favorite teams will be playing in Week 1.

Week 1 will feature plenty of quality matchups. The Seattle Seahawks will be kickstarting the season by hosting the New England Patriots in a Super Bowl 60 rematch at Lumen Field in the NFL's first Wednesday opener since 2012. The next day, the San Francisco 49ers and Los Angeles Rams will tangle down under in the league's first-ever Australia game.

Add in tasty Week 1 matchups between the Buffalo Bills and Houston Texans and there is no shortage of quality clashes for NFL fans to anticipate.

The schedule release will also provide bettors a first glimpse at how the NFL's teams match up against one another on paper. Football fans and gamblers alike already know which squads are expected to be among the contenders, but the spreads, moneylines and point totals will give everyone a better idea of exactly how each club stacks up against one another.

In Week 1, Los Angeles Chargers and Jacksonville Jaguars are among the biggest favorites, as each is projected to win by at least a touchdown. Meanwhile, the Cincinnati Bengals vs. Tampa Bay Buccaneers and Detroit Lions vs. New Orleans Saints matchups are expected to be the highest-scoring of the bunch, with point totals exceeding 50.

Here's more to know about the way-too-early betting odds for the first week of the 2026 NFL season.

NFL Week 1 betting odds

Odds courtesy of BetMGM as of May 15.

New England Patriots at Seattle Seahawks

• Spread: Seahawks -4
• Moneyline: Seahawks (-200) | Patriots (+165)
• Over/under: 44.5

San Francisco 49ers vs. Los Angeles Rams

• Spread: Rams -2.5
• Moneyline: Rams (-140) | 49ers (+115)
• Over/under: 49.5

Chicago Bears at Carolina Panthers

• Spread: Bears -2.5
• Moneyline: Bears (-140) | Panthers (+118)
• Over/under: 45.5

Cleveland Browns at Jacksonville Jaguars

• Spread: Jaguars -7.5
• Moneyline: Jaguars (-350) | Browns (+280)
• Over/under: 40.5

Tampa Bay Buccaneers at Cincinnati Bengals

• Spread: Bengals -3.5
• Moneyline: Bengals (-200) | Buccaneers (+165)
• Over/under: 51.5

Baltimore Ravens at Indianapolis Colts

• Spread: Ravens -3.5
• Moneyline: Ravens (-200) | Colts (+165)
• Over/under: 49.5

Atlanta Falcons at Pittsburgh Steelers

• Spread: Steelers -2.5
• Moneyline: Steelers (-135) | Falcons (+115)
• Over/under: 41.5

Buffalo Bills at Houston Texans

• Spread: Bills -1.5
• Moneyline: Bills (-115) | Texans (-105)
• Over/under: 44.5

New York Jets at Tennessee Titans

• Spread: Titans -2.5
• Moneyline: Titans (-150) | Jets (+125)
• Over/under: 38.5

New Orleans Saints at Detroit Lions

• Spread: Lions -6.5
• Moneyline: Lions (-350) | Saints (+280)
• Over/under: 50.5

Arizona Cardinals at Los Angeles Chargers

• Spread: Chargers -10.5
• Moneyline: Chargers (-650) | Cardinals (+475)
• Over/under: 46.5

Miami Dolphins at Las Vegas Raiders

• Spread: Raiders -3
• Moneyline: Raiders (-175) | Dolphins (+145)
• Over/under: 40.5

Washington Commanders at Philadelphia Eagles

• Spread: Eagles -4.5
• Moneyline: Eagles (-225) | Commanders (+185)
• Over/under: 47.5

Green Bay Packers at Minnesota Vikings

• Spread: Packers -1.5
• Moneyline: Packers (-125) | Vikings (+105)
• Over/under: 45.5

Dallas Cowboys at New York Giants

• Spread: Cowboys -2.5
• Moneyline: Cowboys (-150) | Giants (+125)
• Over/under: 48.5

Denver Broncos at Kansas City Chiefs

• Spread: Chiefs -2.5
• Moneyline: Chiefs (-150) | Broncos (+125)
• Over/under: 42.5

Full NFL Week 1 schedule

Wednesday, Sept. 9

• Seattle Seahawks vs. New England Patriots, 8:20 p.m., NBC

Thursday, Sept. 10

• San Francisco 49ers vs. Los Angeles Rams, 8:35 p.m., Netflix

Sunday, Sept. 13

• Indianapolis Colts vs. Baltimore Ravens, 1 p.m., CBS
• Houston Texans vs. Buffalo Bills, 1 p.m., CBS
• Jacksonville Jaguars vs. Cleveland Browns, 1 p.m., CBS
• Tennessee Titans vs. New York Jets, 1 p.m., CBS
• Pittsburgh Steelers vs. Atlanta Falcons, 1 p.m., Fox
• Carolina Panthers vs. Chicago Bears, 1 p.m., Fox
• Cincinnati Bengals vs. Tampa Bay Buccaneers, 1 p.m., Fox
• Detroit Lions vs. New Orleans Saints, 1 p.m., Fox
• Los Angeles Chargers vs. Arizona Cardinals, 4:25 p.m., CBS
• Minnesota Vikings vs. Green Bay Packers, 4:25 p.m., CBS
• Las Vegas Raiders vs. Miami Dolphins, 4:25 p.m., Fox
• Philadelphia Eagles vs. Washington Commanders, 4:25 p.m., Fox
• New York Giants vs. Dallas Cowboys, 8:20 p.m., NBC

Monday, Sept. 14

• Kansas City Chiefs vs. Denver Broncos, 8 p.m., ESPN/ABC

Super Bowl 61 odds

The Los Angeles Rams are the early favorites to win Super Bowl 61. Below are the latest odds for every team to hoist the Lombardi Trophy, courtesy of BetMGM.

• Los Angeles Rams: +800
• Seattle Seahawks: +950
• Baltimore Ravens: +1000
• Buffalo Bills: +1000
• Detroit Lions: +1500
• Green Bay Packers: +1500
• Philadelphia Eagles: +1500
• Kansas City Chiefs: +1600
• Los Angeles Chargers: +1600
• Denver Broncos: +1700
• New England Patriots: +1800
• San Francisco 49ers: +1800
• Houston Texans: +2000
• Chicago Bears: +2500
• Cincinnati Bengals: +2500
• Dallas Cowboys: +2500
• Jacksonville Jaguars: +2500
• Tampa Bay Buccaneers: +4000
• Indianapolis Colts: +5000
• Minnesota Vikings: +5000
• New York Giants: +6600
• Washington Commanders: +6600
• Atlanta Falcons: +8000
• Pittsburgh Steelers: +8000
• Carolina Panthers: +10000
• New Orleans Saints: +10000
• Las Vegas Raiders: +15000
• Tennessee Titans: +15000
• Arizona Cardinals: +25000
• Cleveland Browns: +25000
• Miami Dolphins: +25000
• New York Jets: +25000