College Football

Ole Miss vs. Tulane: College Football Playoff picks, predictions odds

Dec. 18, 2025, 5:09 a.m. ET

The Ole Miss Rebels (11-1) and the Tulane Green Wave (11-2) are set to face off in the College Football Playoff on Saturday, Dec. 20 in Oxford, Mississippi and USA TODAY's panel of college football experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff, including live updated odds and how to watch.

Tulane vs. Ole Miss live odds, moneyline, over/under

Opening Lines

Spread: Ole Miss (-16.5)
Moneyline: Ole Miss (-900), Tulane (+610)
Over/Under: 56.5

Tulane vs. Ole Miss picks against the spread

Austin Curtright: Ole Miss (-17.5)

Ole Miss destroyed Tulane in its first meeting this season, taking down the Green Wave 45-10 in nonconference play. The Rebels could make this game ugly fast, even without Lane Kiffin calling plays.

Ehsan Kassim: Tulane (+17.5)

Ole Miss is the better team and wins by a multiple-score margin. However, without Lane Kiffin, the Rebels have a harder time this go-around, with Jon Sumrall's final game with the Green Wave ending in a closer-than-expected loss.

Craig Meyer: Tulane (+17.5)

Ole Miss' 35-point win over Tulane in September may make this line seem small, but I expect the Green Wave to make some adjustments and make things occasionally uncomfortable for a Rebels team playing under a new head coach (albeit one who was already on staff). Tulane won't win, but I like it to cover.

2025-26 Bowl Game Picks, Predictions, Odds

How to watch the 2025 College Football Playoff

Matchup: Ole Miss Rebels (11-1) vs. Tulane Green Wave (11-2)
Date: Saturday, Dec. 20 at 3:30 p.m.
Venue: Vaught-Hemingway Stadium at Hollingsworth Field
Location: Oxford, Mississippi
TV Station: TNT

College Football Playoff updated odds

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