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NFL

Buffalo Bills at New York Jets: Predictions, picks and odds for NFL Week 2 game

Sept. 11, 2025, 6:06 a.m. ET

The Buffalo Bills (1-0) visit the New York Jets (0-1) at MetLife Stadium in East Rutherford for a Week 2 showdown, and USA TODAY's panel of NFL experts have locked in their picks and predictions for the action. Here's everything you need to know before kickoff on Sunday, September 14, including live updated odds and injury report news.

Jets vs. Bills live odds, moneyline, over/under

Get the edge with our exclusive NFL betting picks

Jets vs. Bills picks against the spread

NameWeek 1 Record ATS
Christopher Bumbaca7-7-2
Lorenzo Reyes7-7-2
Blake Schuster7-7-2
Jordan Mendoza6-8-2
Jon Hoefling6-8-2
Tyler Dragon5-9-2

Tyler Dragon: Buffalo Bills (-6.5)

Josh Allen is an early front runner for MVP after his Week 1 performance. The Jets will make it tough on him, but Buffalo is the better team.

Christopher Bumbaca: Buffalo Bills (-6.5)

Magic number 7 here. Jets will look good again though, Buffalo just the dominant force in the AFC East matchup.

Jon Hoefling: Buffalo Bills (-6.5)

As great as Justin Fields looked in Week 1, he is still not in the same atmosphere as Josh Allen. Bills by two scores.

Jordan Mendoza: New York Jets (+6.5)

How will Josh Allen and company follow up that electric comeback? They should be able to get past the Jets, but Justin Fields and company look real promising. Another high-scoring game could be in store.

Lorenzo Reyes: New York Jets (+6.5)

I think the Bills win this game, but I think the Jets are better than most people think they are. If New York can continue to be a threat on the ground like it was against a very good Steelers defense, I see this one being closer than a touchdown.

Blake Schuster: Buffalo Bills (-6.5)

The Jets might not be awful, but the Buffalo Bills are on another level of great right now.

Jets vs. Bills updated injury report

NFL Week 2 picks, predictions odds

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